Avanafil is used to prevent the onset or reverse the progression of erectile dysfunction. A major breakthrough in this area of investigation was made by the canadian pharmacologist. Methotrexate sodium 2.5 mg/0.6 ml (maximum dose 40 mg/m ^2^), intralesional corticosteroids (1.0 μg/0.3 ml) and intralesional triamcinolone acetonide (5 mg/ml) injections.