Effects such as increased appetite; mood changes (increased aggression, aggression, agitation, depression and anxiety); insomnia; nervousness; irritability; increased appetite (increased after eating); increased sensitivity to cold; constipation (common with higher doses); constipation; dry skin; hair loss; depression; decreased libido; hot flashes. Since pamelor is an important and commonly used drug, its use is not well regulated. This interaction is a serious risk so do not take it if you are taking drugs that interact with it including the following:.